Title : Why the first self-binding peptide of human c-Src kinase does not contain class II motif but can bind to its cognate Src homology 3 domain in class II mode?

Pub. Date : 2021 Jan

PMID : 31872783






1 Functional Relationships(s)
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1 In addition, the only proline residue Pro250 of fSBP segment is also required for the segment recognition by SH3 domain in c-Src kinase context; lack of Pro250 residue the segment exhibits considerable disorder and cannot maintain in PPII helical conformation, thus largely impairing the domain-segment binding capability. isoleucyl-prolyl-proline C-terminal Src kinase Homo sapiens