Pub. Date : 2019 Dec 17
PMID : 31851937
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Insertion of copper into its catalytically active subunits, including COX2, is a complex process that requires metallochaperones and redox proteins including SCO1, SCO2, and COA6, a recently discovered protein whose molecular function is unknown. | Copper | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | To uncover the molecular mechanism by which COA6 and SCO proteins mediate copper delivery to COX2, we have solved the solution structure of COA6, which reveals a coiled-coil-helix-coiled-coil-helix domain typical of redox-active proteins found in the mitochondrial inter-membrane space. | Copper | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 3 | Accordingly, we demonstrate that COA6 can reduce the copper-coordinating disulfides of its client proteins, SCO1 and COX2, allowing for copper binding. | Copper | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 4 | Accordingly, we demonstrate that COA6 can reduce the copper-coordinating disulfides of its client proteins, SCO1 and COX2, allowing for copper binding. | Copper | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |