Title : Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk.

Pub. Date : 2019 Dec 17

PMID : 31851935






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Metformin interrupts bidirectional signaling between tumor and mesothelial cells by blocking OvCa cell TGF-beta signaling and mesothelial cell production of CCL2 and IL-8. Metformin C-X-C motif chemokine ligand 8 Homo sapiens
2 Disruption of HIF1alpha-driven IL-8 signaling in mesothelial cells by metformin results in reduced OvCa invasion in an organotypic 3D model. Metformin C-X-C motif chemokine ligand 8 Homo sapiens