Pub. Date : 2019 Dec 17
PMID : 31851935
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Metformin interrupts bidirectional signaling between tumor and mesothelial cells by blocking OvCa cell TGF-beta signaling and mesothelial cell production of CCL2 and IL-8. | Metformin | C-X-C motif chemokine ligand 8 | Homo sapiens |
2 | Disruption of HIF1alpha-driven IL-8 signaling in mesothelial cells by metformin results in reduced OvCa invasion in an organotypic 3D model. | Metformin | C-X-C motif chemokine ligand 8 | Homo sapiens |