Title : Modification of the lead molecule: Tryptophan and piperidine appended triazines reversing inflammation and hyeperalgesia in rats.

Pub. Date : 2020 Jan 15

PMID : 31843462






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Selective for COX-2 over COX-1, compound 10 exhibited IC50 0.02 microM for COX-2 and reversed acetic acid induced inflammation in rats by 73% when used at 10 mg kg-1 dose and the same dose of the compound also rescued the animals from inflammatory phase of formalin induced hyperalgesia. Acetic Acid cytochrome c oxidase II, mitochondrial Rattus norvegicus