Title : New 20-hydroxycholesterol-like compounds with fluorescent NBD or alkyne labels: Synthesis, in silico interactions with proteins and uptake by yeast cells.

Pub. Date : 2020 Mar

PMID : 31836520






1 Functional Relationships(s)
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1 In silico computations demonstrated the compounds possess good membrane permeability and can bind within active sites of known 20-hydroxycholesterol targets (e.g. Smoothened and yeast Osh4) and some other sterol-binding proteins (human LXRbeta and STARD1; yeast START-kins Lam4S2 and Lam2S2). Sterols steroidogenic acute regulatory protein Homo sapiens