Title : Nicotine attenuates concanavalin A-induced liver injury in mice by regulating the α7-nicotinic acetylcholine receptor in Kupffer cells.

Pub. Date : 2020 Jan

PMID : 31835083






3 Functional Relationships(s)
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1 Additionally, the expression of alpha7-nAChR on KCs was dramatically increased by nicotine treatment, and the protective effects of nicotine on ConA-induced liver injury were significantly suppressed by treatment with methyllycaconitine (MLA), a specific alpha7-nAChR antagonist. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 Additionally, the expression of alpha7-nAChR on KCs was dramatically increased by nicotine treatment, and the protective effects of nicotine on ConA-induced liver injury were significantly suppressed by treatment with methyllycaconitine (MLA), a specific alpha7-nAChR antagonist. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
3 This study suggests that nicotine increases alpha7-nAChR-mediated cholinergic activity in KCs resulting in decrease of ConA-induced autoimmune hepatitis through inhibiting NF-kappaB signaling. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus