Pub. Date : 2019 Dec 6
PMID : 31817810
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Vitamin C Inhibits Triple-Negative Breast Cancer Metastasis by Affecting the Expression of YAP1 and Synaptopodin 2. | Ascorbic Acid | synaptopodin 2 | Homo sapiens |
| 2 | Vitamin C treatment upregulates the expression of synaptopodin 2 and downregulates the expression of the transcription coactivator YAP1, both genes in the Hippo pathway. | Ascorbic Acid | synaptopodin 2 | Homo sapiens |
| 3 | Further experiments showed that vitamin C treatment inhibits F-actin assembly and lamellipodia formation, which correlates with the changes in SYNPO2 and YAP1 expression. | Ascorbic Acid | synaptopodin 2 | Homo sapiens |
| 4 | Overall, these results suggest that vitamin C inhibits TNBC metastasis by affecting the expression of SYNPO2 and YAP1. | Ascorbic Acid | synaptopodin 2 | Homo sapiens |