Title : Variations in the C-unit of bedaquiline provides analogues with improved biology and pharmacology.

Pub. Date : 2020 Jan 1

PMID : 31810890






1 Functional Relationships(s)
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1 Analogues of the anti-tuberculosis drug bedaquiline, bearing a 3,5-dimethoxy-4-pyridyl C-unit, retain high anti-bacterial potency yet exert less inhibition of the hERG potassium channel, in vitro, than the parent compound. Potassium ETS transcription factor ERG Homo sapiens