Title : Reactive oxygen/nitrogen species contribute substantially to the antileukemia effect of APO866, a NAD lowering agent.

Pub. Date : 2019 Nov 19

PMID : 31803365






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Genetic or pharmacologic inhibition of PARP1 prevented hydrogen peroxide accumulation, caspase activation, mitochondria depolarization, ATP loss and abrogates APO866-induced cell death, suggesting that the integrity of PARP1 status is required for cell death. Hydrogen Peroxide poly(ADP-ribose) polymerase 1 Homo sapiens