Title : Validation of Plasmodium falciparum dUTPase as the target of 5'-tritylated deoxyuridine analogues with anti-malarial activity.

Pub. Date : 2019 Dec 3

PMID : 31796083






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Deoxyuridine 5"-triphosphate nucleotido-hydrolase (dUTPase) is responsible for the hydrolysis of dUTP to dUMP within the parasite and has been proposed as an essential step in pyrimidine metabolism by providing dUMP for thymidylate biosynthesis. 2'-deoxyuridylic acid Deoxyuridine triphosphatase Drosophila melanogaster
2 Deoxyuridine 5"-triphosphate nucleotido-hydrolase (dUTPase) is responsible for the hydrolysis of dUTP to dUMP within the parasite and has been proposed as an essential step in pyrimidine metabolism by providing dUMP for thymidylate biosynthesis. 2'-deoxyuridylic acid Deoxyuridine triphosphatase Drosophila melanogaster