Title : Scutellarin Exerts Anti-Inflammatory Effects in Activated Microglia/Brain Macrophage in Cerebral Ischemia and in Activated BV-2 Microglia Through Regulation of MAPKs Signaling Pathway.

Pub. Date : 2020 Jun

PMID : 31792810






4 Functional Relationships(s)
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1 Furthermore, expression of p-p38 along with that of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta(IL-1beta), and inducible nitric oxide synthase (iNOS) in LPS-activated microglia subjected to pretreatment with p38 inhibitor SB203580, p38 activator sc-201214, scutellarin, or a combination of them was evaluated. scutellarin mitogen activated protein kinase 14 Rattus norvegicus
2 FINDINGS: Scutellarin markedly attenuated the expression of p-p38, p-JNK in AM/BM in MCAO rats and in vitro. scutellarin mitogen activated protein kinase 14 Rattus norvegicus
3 CONCLUSIONS: The results suggest that scutellarin down-regulates the expression of proinflammatory mediators in AM/BM through suppressing the p-JNK and p-p38 MAPKs. scutellarin mitogen activated protein kinase 14 Rattus norvegicus
4 Besides, p38 MAPKs activator reverses the effect of scutellarin. scutellarin mitogen activated protein kinase 14 Rattus norvegicus