Pub. Date : 2020 Jan
PMID : 31782272
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rapamycin inhibited the activation of the mTOR signaling pathway, down-regulated the expression of downstream proteins p70S6K and 4EBP1, reduced the collagen deposition and the production of fibrosis-inducing factors, including TGF-beta and CTGF in hyperoxia-induced lung injury rats. | Sirolimus | mechanistic target of rapamycin kinase | Rattus norvegicus |
| 2 | CONCLUSIONS: Rapamycin may be useful for the treatment of hyperoxia-induced acute lung injury (ALI) by inhibiting the activation of mTOR signaling pathway. | Sirolimus | mechanistic target of rapamycin kinase | Rattus norvegicus |