Pub. Date : 2020 Feb
PMID : 31782083
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We provide evidence that eIF4E phosphorylation is regulated by mTORC1 by virtue of its interaction with Raptor through a novel TPTPNPP motif and consequent phosphorylation invitro and in vivo in a Rapamycin-sensitive manner. | Sirolimus | eukaryotic translation initiation factor 4E | Homo sapiens |
| 2 | While we show that phosphorylation pattern of eIF4E responds faithfully to Rapamycin inhibition, the prolonged exposure to Rapamycin rescues the loss of eIF4E phosphorylation through Mnk1 activation. | Sirolimus | eukaryotic translation initiation factor 4E | Homo sapiens |
| 3 | While we show that phosphorylation pattern of eIF4E responds faithfully to Rapamycin inhibition, the prolonged exposure to Rapamycin rescues the loss of eIF4E phosphorylation through Mnk1 activation. | Sirolimus | eukaryotic translation initiation factor 4E | Homo sapiens |
| 4 | We also present evidence that eIF4E interacts with the amino terminal domain of S6K1 in a phospho-dependent manner, and this interaction is instrumental in overriding Rapamycin inhibition of S6K1. | Sirolimus | eukaryotic translation initiation factor 4E | Homo sapiens |