Title : mPRĪ± mediates P4/Org OD02-0 to improve the sensitivity of lung adenocarcinoma to EGFR-TKIs via the EGFR-SRC-ERK1/2 pathway.

Pub. Date : 2020 Feb

PMID : 31777985






2 Functional Relationships(s)
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1 In this study, we identified that the expression of membrane progesterone receptor alpha (mPRalpha) was associated with EGFR mutations in lung adenocarcinoma patients and subsequently affected the efficacy of EGFR-TKIs. Progesterone S100 calcium binding protein A6 (calcyclin) Mus musculus
2 Progesterone (P4) or its derivative Org OD02-0 (Org), which is mediated by mPRalpha, increases the function of EGFR-TKIs to suppress the proliferation, migration, and invasion of lung adenocarcinoma cells in vitro and in vivo. Progesterone S100 calcium binding protein A6 (calcyclin) Mus musculus