Title : Investigation of Modulatory Effect of Pinolenic Acid (PNA) on Inflammatory Responses in Human THP-1 Macrophage-Like Cell and Mouse Models.

Pub. Date : 2020 Apr

PMID : 31776889






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Using human THP-1 macrophage, we first confirmed that incorporation of PNA into cellular phospholipids suppressed the production of interleukin-6 (IL-6) (by 46%), tumor necrosis factor-alpha (TNF-alpha) (by 18%), and prostaglandin E2 (PGE2) (by 87%), and the expression of type-2 cyclooxygenase (COX-2) (by 27%). 5,9,12-octadecatrienoic acid interleukin 6 Homo sapiens
2 Using human THP-1 macrophage, we first confirmed that incorporation of PNA into cellular phospholipids suppressed the production of interleukin-6 (IL-6) (by 46%), tumor necrosis factor-alpha (TNF-alpha) (by 18%), and prostaglandin E2 (PGE2) (by 87%), and the expression of type-2 cyclooxygenase (COX-2) (by 27%). 5,9,12-octadecatrienoic acid interleukin 6 Homo sapiens