Pub. Date : 2020 Mar
PMID : 31770578
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | While the mechanism in unknown, we tested the effect of l-ornithine, since it is abundantly present in PT luminal fluid and can activate calcium-sensing receptor (CaSR), a GPCR, expressed in the PT luminal membrane. | polyornithine | calcium sensing receptor | Homo sapiens |
| 2 | We used human kidney 2 (HK-2) cells, a PT cells line, and performed Ca2+ imaging and electrophysiological experiments to show that l-ornithine has a concentration-dependent effect on CaSR activation. | polyornithine | calcium sensing receptor | Homo sapiens |
| 3 | Moreover, l-ornithine-activation of CaSR can reverse ROS production and apoptosis via mitogen-activated protein kinase p38 activation. | polyornithine | calcium sensing receptor | Homo sapiens |