Title : Variability in Loss of Multiple Enzyme Activities Due to the Human Genetic Variation P284T Located in the Flexible Hinge Region of NADPH Cytochrome P450 Oxidoreductase.

Pub. Date : 2019

PMID : 31749697






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Electron transfer in POR occurs from NADH to FAD to FMN, and the flexible hinge region in POR is essential for domain movements to bring the FAD and FMN close together for electron transfer. Flavin-Adenine Dinucleotide formin 1 Homo sapiens
2 Electron transfer in POR occurs from NADH to FAD to FMN, and the flexible hinge region in POR is essential for domain movements to bring the FAD and FMN close together for electron transfer. Flavin-Adenine Dinucleotide formin 1 Homo sapiens
3 Electron transfer in POR occurs from NADH to FAD to FMN, and the flexible hinge region in POR is essential for domain movements to bring the FAD and FMN close together for electron transfer. Flavin-Adenine Dinucleotide formin 1 Homo sapiens
4 Electron transfer in POR occurs from NADH to FAD to FMN, and the flexible hinge region in POR is essential for domain movements to bring the FAD and FMN close together for electron transfer. Flavin-Adenine Dinucleotide formin 1 Homo sapiens
5 The negative impact of P284T mutation in the hinge region of POR seems to be due to disruption of FAD to FMN electron transfer. Flavin-Adenine Dinucleotide formin 1 Homo sapiens