Pub. Date : 2020 Jan
PMID : 31746354
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Honokiol antagonizes doxorubicin-induced cardiomyocyte senescence by inhibiting TXNIP-mediated NLRP3 inflammasome activation. | Doxorubicin | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | Hnk also inhibited TXNIP expression and NLRP3 inflammasome activation in Dox-stimulated H9c2 cardiomyocytes. | Doxorubicin | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | When TXNIP expression was enforced by adenovirus-mediated gene overexpression, the NLRP3 inflammasome was activated, which led to inhibition of the anti-inflammation and anti-senescence effects of Hnk on H9c2 cardiomyocytes under Dox treatment. | Doxorubicin | NLR family pyrin domain containing 3 | Homo sapiens |