Pub. Date : 2019 Dec 15
PMID : 31730866
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | KEY FINDINGS: Results showed that separate treatment with 10 mg/kg BW tofacitinib and 100 mg/kg BW aspirin significantly (P < 0.05) decreased tumour necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6) and serum amyloid A when compared to diabetic untreated rats. | tofacitinib | tumor necrosis factor | Rattus norvegicus |
| 2 | However, the combined therapy (10 mg/kg BW tofacitinib and 100 mg/kg BW aspirin) significantly decreased the levels of TNF-alpha, IL-6, serum amyloid A, HOMA-IR, blood glucose level and SOC-3 gene expression but significantly (P < 0.05) improved glucose homoestasis, insulin secretion, HOMA-beta and GLUT-4 gene expression when compared to diabetic untreated rat. | tofacitinib | tumor necrosis factor | Rattus norvegicus |