Title : Inhibition of JAK-STAT and NF-κB signalling systems could be a novel therapeutic target against insulin resistance and type 2 diabetes.

Pub. Date : 2019 Dec 15

PMID : 31730866






3 Functional Relationships(s)
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1 KEY FINDINGS: Results showed that separate treatment with 10 mg/kg BW tofacitinib and 100 mg/kg BW aspirin significantly (P < 0.05) decreased tumour necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6) and serum amyloid A when compared to diabetic untreated rats. tofacitinib interleukin 6 Rattus norvegicus
2 KEY FINDINGS: Results showed that separate treatment with 10 mg/kg BW tofacitinib and 100 mg/kg BW aspirin significantly (P < 0.05) decreased tumour necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6) and serum amyloid A when compared to diabetic untreated rats. tofacitinib interleukin 6 Rattus norvegicus
3 However, the combined therapy (10 mg/kg BW tofacitinib and 100 mg/kg BW aspirin) significantly decreased the levels of TNF-alpha, IL-6, serum amyloid A, HOMA-IR, blood glucose level and SOC-3 gene expression but significantly (P < 0.05) improved glucose homoestasis, insulin secretion, HOMA-beta and GLUT-4 gene expression when compared to diabetic untreated rat. tofacitinib interleukin 6 Rattus norvegicus