Title : P2Y12 receptor mediates microglial activation via RhoA/ROCK pathway in the trigeminal nucleus caudalis in a mouse model of chronic migraine.

Pub. Date : 2019 Nov 13

PMID : 31722730






3 Functional Relationships(s)
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1 RESULTS: The protein levels of P2Y12R, GTP-RhoA, ROCK2, CGRP, c-fos, and inducible nitric oxide synthase (iNOS) in the TNC were increased after recurrent NTG injection. Nitroglycerin nitric oxide synthase 2, inducible Mus musculus
2 RESULTS: The protein levels of P2Y12R, GTP-RhoA, ROCK2, CGRP, c-fos, and inducible nitric oxide synthase (iNOS) in the TNC were increased after recurrent NTG injection. Nitroglycerin nitric oxide synthase 2, inducible Mus musculus
3 In addition, inhibiting P2Y12R and ROCK2 activities suppressed NTG-induced microglial morphological changes (process retraction) and iNOS production in the TNC. Nitroglycerin nitric oxide synthase 2, inducible Mus musculus