Title : p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma.

Pub. Date : 2019

PMID : 31720078






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Enhancer of zeste homolog 2 (EZH2) mediates epigenetic gene silencing via tri-methylation of histone H3 lysine 27 (H3K27-me3). tyrosyl-lysine enhancer of zeste 2 polycomb repressive complex 2 subunit Homo sapiens
2 Enhancer of zeste homolog 2 (EZH2) mediates epigenetic gene silencing via tri-methylation of histone H3 lysine 27 (H3K27-me3). tyrosyl-lysine enhancer of zeste 2 polycomb repressive complex 2 subunit Homo sapiens