Title : Catalytic Hydrolysis Mechanism of Cocaine by Human Carboxylesterase 1: An Orthoester Intermediate Slows Down the Reaction.

Pub. Date : 2019 Nov 9

PMID : 31717501






2 Functional Relationships(s)
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1 Based on this finding, we propose that hCES1 substrates with beta-aminocarboxylester structure might form orthoester intermediates in hCES1-catalyzed hydrolysis, and therefore prolong their in vivo half-life. 5alpha-pregnane-3beta,11beta,20beta,21-tetrol carboxylesterase 1 Homo sapiens
2 Based on this finding, we propose that hCES1 substrates with beta-aminocarboxylester structure might form orthoester intermediates in hCES1-catalyzed hydrolysis, and therefore prolong their in vivo half-life. 5alpha-pregnane-3beta,11beta,20beta,21-tetrol carboxylesterase 1 Homo sapiens