Pub. Date : 2019 Nov 9
PMID : 31717501
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Catalytic Hydrolysis Mechanism of Cocaine by Human Carboxylesterase 1: An Orthoester Intermediate Slows Down the Reaction. | Cocaine | carboxylesterase 1 | Homo sapiens |
| 2 | In this work, we studied the catalytic hydrolysis mechanism of hCES1 by the quantum mechanics computation method, using cocaine as a model substrate. | Cocaine | carboxylesterase 1 | Homo sapiens |
| 3 | Moreover, orthoester intermediates were found in hCES1-catalyzed cocaine hydrolysis reaction, which significantly elevate the free energy barrier and slow down the reaction. | Cocaine | carboxylesterase 1 | Homo sapiens |