Title : Increase in surface expression of transferrin receptors on cultured hepatocytes of adult rats in response to iron deficiency.

Pub. Date : 1988 Oct 15

PMID : 3170563






2 Functional Relationships(s)
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1 Following 24 h of treatment with the iron chelator, desferrioxamine, or with succinylacetone, an inhibitor of heme synthesis, the number of TfR at the cell surface was increased severalfold, with no significant change in receptor affinity (KD) for transferrin. succinylacetone transferrin receptor Rattus norvegicus
2 Hemin decreased surface TfR expression and counteracted the enhancing effects of desferrioxamine or succinylacetone on TfR expression. succinylacetone transferrin receptor Rattus norvegicus