Title : Substrate structure-activity relationship reveals a limited lipopolysaccharide chemotype range for intestinal alkaline phosphatase.

Pub. Date : 2019 Dec 13

PMID : 31704704






1 Functional Relationships(s)
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1 We found that the 1- and 4"-lipid A phosphate groups critical in TLR4/MD2 signaling become susceptible to hydrolysis only after de-O-acylation of ester linked primary acyl chains on lipid A. Lipid A toll like receptor 4 Homo sapiens