Title : Capsaicin-Induced Impairment of Functional Network Dynamics in Mouse Hippocampus via a TrpV1 Receptor-Independent Pathway: Putative Involvement of Na+/K+-ATPase.

Pub. Date : 2020 Feb

PMID : 31701438






10 Functional Relationships(s)
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1 Capsaicin-Induced Impairment of Functional Network Dynamics in Mouse Hippocampus via a TrpV1 Receptor-Independent Pathway: Putative Involvement of Na+/K+-ATPase. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
2 The vanilloid compound capsaicin (Cp) is best known to bind to and activate the transient receptor potential vanilloid receptor-1 (TrpV1). Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
3 The vanilloid compound capsaicin (Cp) is best known to bind to and activate the transient receptor potential vanilloid receptor-1 (TrpV1). Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
4 The vanilloid compound capsaicin (Cp) is best known to bind to and activate the transient receptor potential vanilloid receptor-1 (TrpV1). Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
5 The vanilloid compound capsaicin (Cp) is best known to bind to and activate the transient receptor potential vanilloid receptor-1 (TrpV1). Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
6 A growing number of studies use capsaicin as a tool to study the role of TrpV1 in the central nervous system (CNS). Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
7 Although most of capsaicin"s CNS effects have been reported to be mediated by TrpV1 activation, evidence exists that capsaicin can also trigger functional changes in hippocampal activity independently of TrpV1. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
8 Recently, we have reported that capsaicin induces impairment in hippocampal gamma oscillations via a TrpV1-independent pathway. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
9 In conclusion, our study shows that capsaicin in a TrpV1-independent manner and possibly involving Na+/K+-ATPase activity can impair cognition-relevant functional network dynamics such as gamma oscillations and provides important data regarding the use of capsaicin as a tool to study TrpV1 function in the CNS. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
10 In conclusion, our study shows that capsaicin in a TrpV1-independent manner and possibly involving Na+/K+-ATPase activity can impair cognition-relevant functional network dynamics such as gamma oscillations and provides important data regarding the use of capsaicin as a tool to study TrpV1 function in the CNS. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus