Pub. Date : 2019 Nov 1
PMID : 31701079
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This study aimed to determine whether placental protein expressions of CYP27B1, vitamin D receptor (VDR), and CYP24A1 are impaired in GDM and to investigate the effect of a 25OHD treatment on IL-6 secretion by GDM trophoblasts compared with normoglycemic (NG) trophoblasts. | 1,25,26-trihydroxyvitamin D3 | interleukin 6 | Homo sapiens |
| 2 | In cultured trophoblasts (two groups; n = 5 NG and n = 5 GDM-d), exposure to increasing 25OHD concentrations significantly decreased IL-6 secretion in the GDM-d group only (P = 0.006). | 1,25,26-trihydroxyvitamin D3 | interleukin 6 | Homo sapiens |
| 3 | After treatment with 25OHD (2000 nM), IL-6 secretion was lower in the GDM-d group compared with the NG group (P = 0.03). | 1,25,26-trihydroxyvitamin D3 | interleukin 6 | Homo sapiens |