Title : Molecular Mechanisms and Therapeutics for SBMA/Kennedy's Disease.

Pub. Date : 2019 Oct

PMID : 31686397






8 Functional Relationships(s)
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1 Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by a polyglutamine (polyQ) expansion in the androgen receptor (AR). polyglutamine androgen receptor Homo sapiens
2 Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by a polyglutamine (polyQ) expansion in the androgen receptor (AR). polyglutamine androgen receptor Homo sapiens
3 Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by a polyglutamine (polyQ) expansion in the androgen receptor (AR). polyglutamine androgen receptor Homo sapiens
4 Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by a polyglutamine (polyQ) expansion in the androgen receptor (AR). polyglutamine androgen receptor Homo sapiens
5 Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by a polyglutamine (polyQ) expansion in the androgen receptor (AR). polyglutamine androgen receptor Homo sapiens
6 Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by a polyglutamine (polyQ) expansion in the androgen receptor (AR). polyglutamine androgen receptor Homo sapiens
7 In the current review, we provide an overview of the system-wide clinical features of SBMA, summarize the structure and function of the AR, discuss both gain-of-function and loss-of-function mechanisms of toxicity caused by polyQ-expanded AR, and describe the cell and animal models utilized in the study of SBMA. polyglutamine androgen receptor Homo sapiens
8 In the current review, we provide an overview of the system-wide clinical features of SBMA, summarize the structure and function of the AR, discuss both gain-of-function and loss-of-function mechanisms of toxicity caused by polyQ-expanded AR, and describe the cell and animal models utilized in the study of SBMA. polyglutamine androgen receptor Homo sapiens