Title : Identification and Assessments of Novel and Potent Small-Molecule Inhibitors of EED-EZH2 Interaction of Polycomb Repressive Complex 2 by Computational Methods and Biological Evaluations.

Pub. Date : 2020 Jan 1

PMID : 31685780






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Among the three core subunits (EZH2, EED and SUZ12) of PRC2, EZH2 is the catalytic subunit that methylates histone H3 lysine 27 (H3K27), while EED is the regulatory subunit. tyrosyl-lysine enhancer of zeste 2 polycomb repressive complex 2 subunit Homo sapiens
2 Among the three core subunits (EZH2, EED and SUZ12) of PRC2, EZH2 is the catalytic subunit that methylates histone H3 lysine 27 (H3K27), while EED is the regulatory subunit. tyrosyl-lysine enhancer of zeste 2 polycomb repressive complex 2 subunit Homo sapiens