Pub. Date : 2020 Jan 3
PMID : 31685549
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Anabolic SIRT4 exerts retrograde control over TORC1 signalling by glutamine sparing in the mitochondria. | arginyl-glutamine | CREB regulated transcription coactivator 1 | Homo sapiens |
| 2 | Mechanistically, we demonstrate that the ability of SIRT4 to inhibit anaplerotic conversion of glutamine to alpha-ketoglutarate potentiates TORC1. | arginyl-glutamine | CREB regulated transcription coactivator 1 | Homo sapiens |
| 3 | Interestingly, we also show that mitochondrial glutamine sparing or utilization is critical for differentially regulating TORC1 under fed and fasted conditions. | arginyl-glutamine | CREB regulated transcription coactivator 1 | Homo sapiens |