Pub. Date : 2019 Sep
PMID : 31649848
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our results indicated that imipenem and cilastatin were substrates of hOAT1 and hOAT3. | Imipenem | solute carrier family 22 member 6 | Homo sapiens |
| 2 | Cilastatin inhibited hOAT1/3-mediated transport of imipenem with IC50 values comparable to the clinical concentration, suggesting the potential to cause a clinical drug-drug interaction (DDI). | Imipenem | solute carrier family 22 member 6 | Homo sapiens |
| 3 | Moreover, imipenem exhibited hOAT1/3-dependent cytotoxicity, which was alleviated by cilastatin and probenecid. | Imipenem | solute carrier family 22 member 6 | Homo sapiens |