Title : Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat.

Pub. Date : 1988 Jul

PMID : 3164865






2 Functional Relationships(s)
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1 Porcine platelet-derived TGF-beta 1 (0.5 micrograms), administered intravenously at the time of PH and 11 hr later, reduced the fraction of hepatocytes engaged in DNA synthesis 22 hr after PH by 67% and inhibited the rate of hepatic [3H]thymidine incorporation by 50%. Tritium transforming growth factor, beta 1 Rattus norvegicus
2 A single dose of 0.5 micrograms of TGF-beta 1 given 11 hr after PH reduced liver [3H]thymidine incorporation by 32%; 4.5 micrograms of TGF-beta 1 or TGF-beta 2 inhibited DNA synthesis by 88% and the labeling index by 86%. Tritium transforming growth factor, beta 1 Rattus norvegicus