Pub. Date : 2020 Feb
PMID : 31648367
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Propranolol is a mechanism-based inhibitor of CYP2D and CYP2D6 in humanized CYP2D6-transgenic mice: effects on activity and drug response. | Propranolol | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 2 | Propranolol is a mechanism-based inhibitor of CYP2D and CYP2D6 in humanized CYP2D6-transgenic mice: effects on activity and drug response. | Propranolol | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 3 | Our purpose was to characterize propranolol as a CYP2D inhibitor in human and mouse, and to develop a method for in vivo manipulation of CYP2D6 enzyme activity which could be used to investigate the role of CYP2D6 in drug-induced behaviours. | Propranolol | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 4 | We also examined the impact of 24 h propranolol pre-treatment on serum levels of the CYP2D6 substrate haloperidol and haloperidol-induced catalepsy. | Propranolol | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 5 | Manipulation of CYP2D with propranolol in vivo in TG and WT mice alters drug response, which will be useful for future investigation of the impact of variation in CYP2D6 on drug interactions and drug responses. | Propranolol | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |