Pub. Date : 2019 Nov 1
PMID : 31646844
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | On the other hand, the hypnotic effect of 3 mg/kg of luteolin was almost completely blocked by caffeine, an antagonist for both adenosine A1 and A2A receptor (A1R and A2AR), 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX), an A1R antagonist, and SCH-58261, an A2AR antagonist. | Luteolin | adenosine A2a receptor | Mus musculus |
| 2 | On the other hand, the hypnotic effect of 3 mg/kg of luteolin was almost completely blocked by caffeine, an antagonist for both adenosine A1 and A2A receptor (A1R and A2AR), 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX), an A1R antagonist, and SCH-58261, an A2AR antagonist. | Luteolin | adenosine A2a receptor | Mus musculus |
| 3 | From the binding affinity assay, we have found that luteolin significantly binds to not only A1R but also A2AR with IC50 of 1.19, 0.84 mug/kg, respectively. | Luteolin | adenosine A2a receptor | Mus musculus |
| 4 | From these results, it has been suggested that luteolin has hypnotic efficacy through A1R and A2AR binding. | Luteolin | adenosine A2a receptor | Mus musculus |