Pub. Date : 1988 May 16
PMID : 3163921
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Role for protein kinase C in the modulation of glomerular PGE2 production by angiotensin II. | Dinoprostone | angiotensinogen | Homo sapiens |
| 2 | Angiotensin II increased PGE2 release from superfused glomeruli, and stimulated labeled inositol phosphate production. | Dinoprostone | angiotensinogen | Homo sapiens |
| 3 | 12-O-Tetradecanoyl phorbol -13-acetate (TPA, 10(-7) M), which stimulates protein kinase C activity in soluble fractions of glomerular homogenates, suppressed angiotensin II actions on inositol phosphate production and PGE2. | Dinoprostone | angiotensinogen | Homo sapiens |
| 4 | Moreover H-7 prolonged the time course of angiotensin II induced inositol phosphate production and enhanced angiotensin II actions on glomerular PGE2 production. | Dinoprostone | angiotensinogen | Homo sapiens |
| 5 | The results support a role for inositol phospholipid hydrolysis through the phospholipase C pathway in the mediation of angiotensin II actions on PGE2 in glomeruli and are consistent with negative modulation of these actions by protein kinase C. | Dinoprostone | angiotensinogen | Homo sapiens |