Title : KLF4 inhibition promotes the expansion of keratinocyte precursors from adult human skin and of embryonic-stem-cell-derived keratinocytes.

Pub. Date : 2019 Dec

PMID : 31636412






2 Functional Relationships(s)
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1 Here, we show that stable and transient downregulation of the transcription factor Kruppel-like factor 4 (KLF4) in keratinocyte precursors from adult skin, using anti-KLF4 RNA interference or kenpaullone, promotes keratinocyte immaturity and keratinocyte self-renewal in vitro, and enhances the capacity for epidermal regeneration in mice. kenpaullone Kruppel-like factor 4 (gut) Mus musculus
2 Here, we show that stable and transient downregulation of the transcription factor Kruppel-like factor 4 (KLF4) in keratinocyte precursors from adult skin, using anti-KLF4 RNA interference or kenpaullone, promotes keratinocyte immaturity and keratinocyte self-renewal in vitro, and enhances the capacity for epidermal regeneration in mice. kenpaullone Kruppel-like factor 4 (gut) Mus musculus