Title : Nitroglycerin Enhances Cisplatin-Induced Cytotoxicity via AKT Inactivation and Thymidylate Synthase Downregulation in Human Lung Cancer Cells.

Pub. Date : 2020

PMID : 31630149






4 Functional Relationships(s)
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1 In this study, NTG decreased TS expression in an AKT, also known as Protein kinase B (PKB) inactivation dependent manner in human lung adenocarcinoma A549 and squamous cell carcinoma H1703 cells. Nitroglycerin AKT serine/threonine kinase 1 Homo sapiens
2 Enhancement of AKT activity by transfection with constitutive active AKT vectors increased the TS expression level as well as the cell survival pretreated by NTG. Nitroglycerin AKT serine/threonine kinase 1 Homo sapiens
3 Enhancement of AKT activity by transfection with constitutive active AKT vectors increased the TS expression level as well as the cell survival pretreated by NTG. Nitroglycerin AKT serine/threonine kinase 1 Homo sapiens
4 Moreover, NTG synergistically enhanced cytotoxicity and cell growth inhibition by cisplatin treatment in NSCLC cells, which were associated with downregulation of TS expression and inactivation of AKT in A549 and H1703 cells. Nitroglycerin AKT serine/threonine kinase 1 Homo sapiens