Pub. Date : 2020 Jan
PMID : 31629169
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A role for peroxiredoxins in H2O2- and MEKK-dependent activation of the p38 signaling pathway. | Hydrogen Peroxide | peroxiredoxin 2 | Homo sapiens |
| 2 | In line with the emerging role of peroxiredoxins as H2O2 sensors and signal transmitters we observe an H2O2-dependent interaction between Mekk1 and the cytosolic peroxiredoxin of Drosophila, Jafrac1. | Hydrogen Peroxide | peroxiredoxin 2 | Homo sapiens |
| 3 | In line with the emerging role of peroxiredoxins as H2O2 sensors and signal transmitters we observe an H2O2-dependent interaction between Mekk1 and the cytosolic peroxiredoxin of Drosophila, Jafrac1. | Hydrogen Peroxide | peroxiredoxin 2 | Homo sapiens |
| 4 | In line with the emerging role of peroxiredoxins as H2O2 sensors and signal transmitters we observe an H2O2-dependent interaction between Mekk1 and the cytosolic peroxiredoxin of Drosophila, Jafrac1. | Hydrogen Peroxide | peroxiredoxin 2 | Homo sapiens |
| 5 | In line with the emerging role of peroxiredoxins as H2O2 sensors and signal transmitters we observe an H2O2-dependent interaction between Mekk1 and the cytosolic peroxiredoxin of Drosophila, Jafrac1. | Hydrogen Peroxide | peroxiredoxin 2 | Homo sapiens |
| 6 | In both organisms, H2O2 induces transient disulfide-linked conjugates between the MAP3K and a typical 2-Cys peroxiredoxin. | Hydrogen Peroxide | peroxiredoxin 2 | Homo sapiens |
| 7 | Indeed, the depletion of cytosolic 2-Cys peroxiredoxins in human cells diminished H2O2-induced activation of p38 MAPK. | Hydrogen Peroxide | peroxiredoxin 2 | Homo sapiens |