Title : Melatonin ameliorates sodium valproate-induced hepatotoxicity in rats.

Pub. Date : 2020 Jan

PMID : 31624995






1 Functional Relationships(s)
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1 VPA administration significantly increased the levels of alpha-GST, MDA, NF-kappaB and of IL-1beta, TNF-alpha gene expression in the liver compared to Group C. Moreover, vacuolization, hydropic degeneration, inflammatory cell infiltration, and sinusoidal congestion were commonly detected in the VPA-treated group along with the highest apoptotic index (TUNEL staining) values. Valproic Acid tumor necrosis factor Rattus norvegicus