Pub. Date : 2019 Oct 14
PMID : 31612866
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | nAChRalpha1 knockdown significantly decreases the nicotine-induced upregulation of p-STAT3, p-Akt and p-mTOR in vitro, while nAChRalpha1 overexpression has the opposite effects. | Nicotine | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | Moreover, there is a direct interaction between STAT3 and nAChRalpha1 that modulates STAT3 nuclear translocation and its binding to the Akt promoter region upon nicotine exposure. | Nicotine | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | Taken together, STAT3 and nAChRalpha1 blockade attenuates nicotine-induced atherosclerosis by reducing the migration and proliferation of vascular smooth muscle cells and inflammation in macrophages via the Akt/mTOR pathway. | Nicotine | thymoma viral proto-oncogene 1 | Mus musculus |