Pub. Date : 2019 Oct 11
PMID : 31603853
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The quantification of the 6beta-OHC/cortisol metabolic ratio as a biomarker of CYP3A4 activity in human urine was used for the assessment of CYP3A4 catalytic activity as a non-invasive test. | Hydrocortisone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Results The ratio of 6-6beta-OHC/cortisol was used as a biomarker to study the taurine and L-carnitine influence on CYP3A4 metabolism of cortisol. | Hydrocortisone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Seven days after the administration of taurine in a dose of 500 mg twice a day, the 6beta-OCH/cortisol ratio was 3.3 +- 0.2, which indicated the increased catalytic activity of CYP3A4 towards cortisol. | Hydrocortisone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | Seven days after the administration of taurine in a dose of 500 mg twice a day, the 6beta-OCH/cortisol ratio was 3.3 +- 0.2, which indicated the increased catalytic activity of CYP3A4 towards cortisol. | Hydrocortisone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | Conclusions The results obtained demonstrated the influence of taurine on 6beta-OCH/cortisol metabolic ratio as a biomarker of CYP3A4 catalytic activity to cortisol. | Hydrocortisone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 6 | Conclusions The results obtained demonstrated the influence of taurine on 6beta-OCH/cortisol metabolic ratio as a biomarker of CYP3A4 catalytic activity to cortisol. | Hydrocortisone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |