Title : T cell-derived soluble glycoprotein GPIbα mediates PGE2 production in human monocytes activated with the vaccine adjuvant MDP.

Pub. Date : 2019 Oct 8

PMID : 31594856






2 Functional Relationships(s)
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1 However, high amounts of PGE2 and the proinflammatory cytokines IL-1beta and IL-6 were secreted by monocytes activated with MDP in the presence of conditioned medium obtained from CD3 bead-isolated T cells (Tc CM) but not from those isolated without CD3 beads. Acetylmuramyl-Alanyl-Isoglutamine interleukin 6 Homo sapiens
2 Antibody-mediated blockade of GPIbalpha or of its receptor, Mac-1 integrin, inhibited the secretion of PGE2, IL-1beta, and IL-6 in MDP + Tc CM-activated monocytes, whereas recombinant GPIbalpha protein increased PGE2 production by MDP-treated monocytes. Acetylmuramyl-Alanyl-Isoglutamine interleukin 6 Homo sapiens