Title : A role for PKD1 in insulin secretion downstream of P2Y1 receptor activation in mouse and human islets.

Pub. Date : 2019 Oct

PMID : 31591827






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Along with insulin, beta-cells co-secrete the neurotransmitter ATP which acts as a positive autocrine signal via P2Y1 receptors to activate phospholipase C and increase the production of diacylglycerol (DAG). Adenosine Triphosphate insulin Homo sapiens
2 Since DAG activates protein kinase D1 (PKD1) to potentiate glucose-stimulated insulin release, we hypothesized that autocrine ATP signaling activates downstream PKD1 to regulate insulin secretion. Adenosine Triphosphate insulin Homo sapiens
3 Since DAG activates protein kinase D1 (PKD1) to potentiate glucose-stimulated insulin release, we hypothesized that autocrine ATP signaling activates downstream PKD1 to regulate insulin secretion. Adenosine Triphosphate insulin Homo sapiens