Title : Fremanezumab inhibits vasodilatory effects of CGRP and capsaicin in rat cerebral artery - Potential role in conditions of severe vasoconstriction.

Pub. Date : 2019 Dec 1

PMID : 31589869






2 Functional Relationships(s)
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1 Capsaicin is used as a pharmacological tool to induce secretion of endogenous perivascular CGRP and our studies confirm that the antibody reach the perivascular sensory synaptic cleft and blocks the vasodilatory response of released CGRP in the present in vitro model. Capsaicin calcitonin-related polypeptide alpha Rattus norvegicus
2 Capsaicin is used as a pharmacological tool to induce secretion of endogenous perivascular CGRP and our studies confirm that the antibody reach the perivascular sensory synaptic cleft and blocks the vasodilatory response of released CGRP in the present in vitro model. Capsaicin calcitonin-related polypeptide alpha Rattus norvegicus