Title : Blocking PERK resuces vascular smooth muscle cells from homocysteine-induced ER stress and apoptosis.

Pub. Date : 2020 Jan 1

PMID : 31585902






3 Functional Relationships(s)
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1 Here, we tested whether blockage of homocysteine (Hcy) induced ERS and subsequent apoptosis in vascular smooth muscle cells can be inhibited by blockage of PERK/eIF2alpha/ATF4/CHOP signaling. Homocysteine DNA damage inducible transcript 3 Homo sapiens
2 Here, we tested whether blockage of homocysteine (Hcy) induced ERS and subsequent apoptosis in vascular smooth muscle cells can be inhibited by blockage of PERK/eIF2alpha/ATF4/CHOP signaling. Homocysteine DNA damage inducible transcript 3 Homo sapiens
3 Long-term Hcy exposure, however, increased the expression of ATF-4 and CHOP and led to apoptosis. Homocysteine DNA damage inducible transcript 3 Homo sapiens