Title : Inhibition of Synovial Macrophage Pyroptosis Alleviates Synovitis and Fibrosis in Knee Osteoarthritis.

Pub. Date : 2019

PMID : 31582897






1 Functional Relationships(s)
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1 Besides, rats treated with the specific caspase1 inhibitor Ac-YVAD-CMK showed less inflammatory reaction and fibrosis, not only in the expression of proinflammatory factors IL-1beta, IL-18, and HMGB1 and fibrosis markers TGF-beta, PLOD2, COL1A1, and TIMP1 but also in the observation of HE staining, Sirius Red staining, and the transverse diameters of the right knees. ac-yvad collagen type I alpha 1 chain Rattus norvegicus