Title : Lysosomotropic agents selectively potentiate thrombin-induced acid hydrolase secretion from platelets.

Pub. Date : 1985 Apr

PMID : 3157989






2 Functional Relationships(s)
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1 Preincubation of platelets with 10 mM NH4Cl for up to 2 hr resulted in a time-dependent and marked stimulation of thrombin-induced secretion of both this enzyme and other acid glycosidases from platelets. Ammonium Chloride coagulation factor II, thrombin Homo sapiens
2 Thrombin-induced secretion of adenine nucleotides from dense granules and of beta-thromboglobulin from alpha granules was slightly enhanced by NH4Cl but was slightly inhibited by methylamine. Ammonium Chloride coagulation factor II, thrombin Homo sapiens