Pub. Date : 2019
PMID : 31571937
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Functional characteristics of CYP3A4 allelic variants on the metabolism of loperamide in vitro. | Loperamide | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Loperamide, identified as a CYP3A4 substrate, is prone to misuse and abuse and has high risks of life-threatening cardiotoxicity. | Loperamide | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Methods: Thus, this study is designed to evaluate the enzymatic characteristics of 29 CYP3A4 alleles toward loperamide in vitro, including the 7 novel CYP3A4 variants (*28-*34). | Loperamide | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | Conclusion: As the first study to identify the properties of these CYP3A4 variants toward loperamide metabolism, our investigation may establish the genotype-phenotype relationship for loperamide, predict an individual"s capability in response to loperamide, and provide some guidance of clinical medication and treatment for loperamide. | Loperamide | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | Conclusion: As the first study to identify the properties of these CYP3A4 variants toward loperamide metabolism, our investigation may establish the genotype-phenotype relationship for loperamide, predict an individual"s capability in response to loperamide, and provide some guidance of clinical medication and treatment for loperamide. | Loperamide | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 6 | Conclusion: As the first study to identify the properties of these CYP3A4 variants toward loperamide metabolism, our investigation may establish the genotype-phenotype relationship for loperamide, predict an individual"s capability in response to loperamide, and provide some guidance of clinical medication and treatment for loperamide. | Loperamide | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 7 | Conclusion: As the first study to identify the properties of these CYP3A4 variants toward loperamide metabolism, our investigation may establish the genotype-phenotype relationship for loperamide, predict an individual"s capability in response to loperamide, and provide some guidance of clinical medication and treatment for loperamide. | Loperamide | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |